Welcome! The Devaraj Lab at UCSD focuses on the design of chemoselective reactions for addressing problems in bottom-up synthetic biology and molecular imaging. Bioconjugation chemistries are some of the most important and commonly used tools in chemical biology. Our interdisciplinary research aims to advance important knowledge in chemical biology by extending the use of bioconjugation reactions into previously unexplored frontiers and challenging preconceived notions of where chemical reactions can be performed. We are part of the Department of Chemistry and Biochemistry.
Devaraj Lab is hiring postdoctoral fellows. Click below if interested in joining the lab.
OUR LATEST NEWS
OUR LATEST RESEARCH
Changing the structure of lipids can play important roles in membrane biology and dysregulation can lead to disease. While artificial membranes have been used to model the properties of native membranes, previous methods have not been able to mimic lipid membrane remodeling. We recently have shown that reversible chemical reactions can be harnessed to achieve spontaneous remodeling of lipids in synthetic membranes.
Though Native Chemical Ligation (NCL) has been ubiquitously used to assemble peptides and proteins, we have used NCL to assemble phospholipids. This enables nonenzymatic formation of phospholipid vesicles/membranes from thioester precursors, mimicking the membrane protein catalyzed assembly of phospholipids in live cells, which also uses long chain thioesters as precursors.