PUBLICATIONS

 
 

 

2019

 

62. A. Bhattacharya, R. Brea, J. Song, R. Bhattacharya, S. K. Sinha, N. K. Devaraj “Single-Chain β-d-Glycopyranosylamides of Unsaturated Fatty Acids: Self-Assembly Properties and Applications to Artificial Cell Development,” J. Phys. Chem. B,  2019, 123(17), 3711-3720.

 

61. A. Bhattacharya, R. Brea, H. Niederholtmeyer, N. K. Devaraj A Minimal Biochemical Route towards de novo Formation of Synthetic Phospholipid Membranes,Nat. Commun., 2019, 10, 300.

-Highlighted in Chemical and Engineering News February 9, 2019, 97, 6 "Simplified Route to Phospholipid Membranes

 

60. A. K. Rudd, R. Brea, N. K. Devaraj Amphiphile-Mediated Depalmitoylation of Proteins in Living Cells, J. Am. Chem. Soc., 2018, 140 (50), 17374-17378.

 

2018

 

59. R. Brea, A. Bhattacharya, R. Bhattacharya, J. Song, S. Sinha, N. K. Devaraj Highly Stable Artificial Cells from Galactopyranose-Derived Single-Chain Amphiphiles, J. Am. Chem. Soc., 2018, 140 (50), 17356-17360.

 

58. H. Niederholtmeyer, C. Chaggan, N. K. Devaraj Communication and quorum sensing in non-living mimics of eukaryotic cells,” Nat. Commun., 2018, 9, 5027.

-Highlighted in Science, 362, 6417, 877, "Artificial Cells Gain Communication Skills"

 

57. N. K. Devaraj “The Future of Bioorthogonal Chemistry,” ACS Cent. Sci., 2018, 4(8), 952-959 

 

56. A. K. Rudd, N. K. Devaraj “Traceless Synthesis of Ceramides in Living Cells Reveals Saturation-Dependent Apoptotic Effects,” Proc. Natl. Acad. Sci. USA, 2018, 115 (29), 7485-7490.

 

55. A. Seoane, R. J. Brea, A. Fuertes, K. Podolsky, N. K. Devaraj “Biomimetic Generation and Remodeling of Phospholipid Membranes by Dynamic Imine Chemistry,” J. Am. Chem. Soc., 2018, 140 (27), pp 8388–8391.

 

54. H. Wu, N. K. Devaraj “Advances in Tetrazine Bioorthogonal Chemistry Driven by the Synthesis of Novel Tetrazines and Dienophiles,” Acc. Chem. Res., 2018, 51 (5), 1249–1259.

 

53. X. Shi, T. Wu, C. M. Cole, N. K. Devaraj, S. Joseph “Optimization of ClpXP activity and protein synthesis in an E. coli extract-based cell-free expression system,” Sci. Rep., 2018, 8 (1), 3488.

 

52. D. Zhang, C. Y. Zhou, K. N. Busby, S. C. Alexander, N. K. Devaraj “Light-activated control of translation by enzymatic covalent mRNA labeling,” Angew. Chem. Int. Ed., 2018, 57 (11), 2822-2826.

 

51. N. K. Devaraj, C. L. Perrin “Approach control. Stereoelectronic origin of geometric constraints on N-to-S and N-to-O acyl shifts in peptides,” Chem. Sci., 2018, 9, 1789-1794.

 

2017

 

50. A. Bhattacharya, R. J. Brea, N. K. Devaraj “De novo vesicle formation and growth: an integrative approach to artificial cells,” Chem. Sci., 2017, 8, 7912-7922.

49. T. Enomoto, R. J. Brea, A. Bhattacharya, N. K. Devaraj “In Situ Lipid Membrane Formation Triggered by an Intramolecular Photoinduced Electron Transfer,” Langmuir, 2017, 34 (3), 750-755.

48. C. Y. Zhou, S. C. Alexander, N. K. Devaraj “Fluorescent Turn-on Probes for Wash-Free mRNA Imaging via Covalent Site-Specific Enzymatic Labeling,” Chem. Sci., 2017, 8, 7169-7173.

47. R. J. Brea, N. K. Devaraj “Continual Reproduction of Self-Assembling Oligotriazole Peptide Nanomaterials,” Nat. Commun., 2017, 8 (1), 730.

 

46. F. Ehret, C. Y. Zhou, S. C. Alexander, D. Zhang, N. K. Devaraj “Site-Specific Covalent Conjugation of Modified mRNA by tRNA Guanine Transglycosylase,” Mol. Pharm., 2017, In Press.

45. S. C. Alexander, N. K. Devaraj “Developing a fluorescent toolbox to shed light on the mysteries of RNA,”  Biochemistry, 2017, 56 (39), pp 5185–5193.

44. N. K. Devaraj, “In Situ Synthesis of Phospholipid Membranes,” J. Org. Chem., 2017, 82 (12), pp 5997–6005.

43. R. J. Brea, C. M. Cole, B. R. Lyda, L. Ye, R. S. Prosser, R. K. Sunahara, N. K. Devaraj, “In Situ Reconstitution of the Adenosine A2A Receptor in Spontaneously Formed Synthetic Liposomes,” J. Am. Chem. Soc., 2017, 139 (10), 3607-3610.

 

42. R. J. Brea, A. Bhattacharya, N. K. Devaraj, “Spontaneous Phospholipid Membrane Formation by Histidine Ligation,” Synlett, 2017, 28(01): 108-112.

 

2016

 

41. R. J. Brea, A. K. Rudd, N. K. Devaraj, “Non-Enzymatic Biomimetic Remodeling of Phospholipids in Synthetic Liposomes,” Proc. Natl. Acad. Sci. USA, 2016, 113 (31), 8589-8594.

 

40. H. Wu, S. C. Alexander, S. Jin, N. K. Devaraj, “A Bioorthogonal Near-infrared Fluorogenic Probe for mRNA Detection,” J. Am. Chem. Soc., 2016, 138 (36), 11429–11432.

 

39. M. D. Hardy, D. Konetski, C. N. Bowman, N. K. Devaraj, “Ruthenium Photoredox-Triggered Phospholipid Formation,” Org. Biomol. Chem., 2016, 14, 5555-5558.

 

38. S. Chowdhuri, C. M. Cole, N. K. Devaraj “Encapsulation of Living Cells within Giant Phospholipid Liposomes Formed by the Inverse-Emulsion TechniqueChemBioChem, 2016, 17 (10), 886-889.

 

37. H. Wu, N. K. Devaraj, “Inverse Electron-Demand Diels–Alder Bioorthogonal Reactions,” Top. Curr. Chem., 2016, 374(1), 1-22.

 

2015

 

36. S. C. Alexander, K. N. Busby, C. M. Cole, C. Zhou, N. K. Devaraj "Site-specific Covalent Labeling of RNA by Enzymatic Transglycosylation,” J. Am. Chem. Soc., 2015, 137(40), 12756-12759.

 

35. C. M. Cole, R. J. Brea, Y. Kim, M. D. Hardy, J. Yang, N. K. Devaraj "Spontaneous Reconstitution of Functional Transmembrane Proteins During Bioorthogonal Phospholipid Membrane Synthesis,” Angew. Chem. Int. Ed., 2015, 54(43), 12738-12742.

 

34. F. Ehret, H. Wu, S. C. Alexander, N. K. Devaraj, “Electrochemical Control of Rapid Bioorthogonal Tetrazine Ligations for Selective Functionalization of Microelectrodes,” J. Am. Chem. Soc., 2015, 137 (28), 8876–8879.

 

33. M. D. Hardy, J. Yang, J. Selimkhanov, C. M. Cole, L. S. Tsimring, N. K. Devaraj "A Self-Reproducing Catalyst Drives Repeated Phospholipid Synthesis and Membrane Growth," Proc. Natl. Acad. Sci. USA, 2015, 112(27), 8187-8192.

-Highlighted in Nature Nanotechnology, August 2015, “Phospholipids Grow Non-stop,” vol. 10, p. 653

 

32. R. J. Brea, M. D. Hardy, N. K. Devaraj, “Towards Self-Assembled Hybrid Artificial Cells: Novel Bottom-Up Approaches to Functional Synthetic Membranes.” Chem. Eur. J., 2015, 21(36), 12564-12570.

 

31. C. Y. Zhou, H. Wu, N. K. Devaraj “Rapid Access to Phospholipid Analogs Using Thiol-Yne Chemistry,” Chem. Sci., 2015, 6, 4365-4372.

 

30. A. K. Rudd, J. M. V. Cuevas, N. K. Devaraj "SNAP-tag Reactive Lipid Anchors Enable Targeted and Spatiotemporally Controlled Localization of Proteins to Phospholipid Membranes," J. Am. Chem. Soc., 2015, 137(15), 4884-4887.

-Highlighted in Chemical & Engineering News, 93(16), April 16, 2015 “Technique Adds Proteins to Membranes at Specific Sites and Times” News of the Week

 

2014

 

29. H. Wu, B. T. Cisneros, C. M. Cole, N. K. Devaraj "Bioorthogonal Tetrazine-Mediated Transfer Reactions Facilitate Reaction Turnover in the Nucleic Acid-Templated Detection of microRNA," J. Am. Chem. Soc., 2014, 136(52), 17942-17945.

 

28. R. J. Brea, C. M. Cole, N. K. Devaraj "In situ Vesicle Formation by Native Chemical Ligation," Angew. Chem. Int. Ed., 2014, 53(51), 14102-14105.

 

27. H. Wu, J. Yang, J. Šečkutė, N. K. Devaraj "In-situ Synthesis of Alkenyl Tetrazines for Highly Fluorogenic Bioorthogonal Live Cell Imaging Probes," Angew. Chem. Int. Ed., 2014, 53 (23), 5805-5809.

 

26. B. Nichols, Z. Qin, J. Yang, D. R. Vera, N. K. Devaraj “68Ga Chelating Bioorthogonal Tetrazine Polymers for the Multistep labeling of Cancer Biomarkers,” Chem. Comm., 2014, 50 (40), 5215-5217.

 

25. J. Yang, Y. Liang, J. Seckute, K. Houk, N. K. Devaraj “Synthesis and Reactivity Comparisons of 1-Methyl-3-Substituted Cyclopropene Minitags for Tetrazine Bioorthogonal Reactions,” Chem. Eur. J., 2014, 20 (12), 3365-3375.

 

2013

 

24. J. Seckute, N. K. Devaraj “Expanding Room for Tetrazine Ligations in the In Vivo Chemistry Toolbox,” Curr. Opin. Chem. Biol., 2013, 17(5), 761-767.

 

23. J. Seckute, J. Yang, N. K. Devaraj “Rapid Oligonucleotide-Templated Fluorogenic Tetrazine Cycloadditions,” Nucl. Acids Res., 2013, 41(15) e148.

 

22. C. M. Cole, J. Yang, J. Šečkutė, N. K.  Devaraj, “Fluorescent Live-Cell Imaging of Metabolically Incorporated Unnatural Cyclopropene-Mannosamine Derivatives,” ChemBioChem, 2013, 14(2), 205-208.

 

2012

 

21. N. K. Devaraj, “Advancing Tetrazine Bioorthogonal Reactions through the Development of New Synthetic Tools," Synlett., 2012, 23(15): 2147-2152.

 

20. J. Yang, J. Seckute, C. M. Cole, N. K. Devaraj "Live-Cell Imaging of Cyclopropene Tags with Fluorogenic Tetrazine Cycloadditions," Angew. Chem. Int. Ed., 2012, 51(30), 7476-7479.

 

19. J. Yang, M. R. Karver, W. Li, S. Sagu, N. K. Devaraj “Metal-Catalyzed One-Pot Synthesis of Tetrazines Directly from Aliphatic Nitriles and Hydrazine,” Angew. Chem. Int. Ed., 2012, 51(21), 5222-5225.

-Highlighted in Chemical & Engineering News, 90(18), April 30, 2012 “Streamlining Tetrazine Synthesis” News of the Week

 

18. I. Budin, N. K. Devaraj “Membrane Assembly Driven by a Biomimetic Coupling Reaction,” J. Am. Chem. Soc., 2012, 134(2), 751-753.

 

Graduate and Postdoctoral Publications

 

17. N. K. Devaraj, G. M. Thurber, E. J. Keliher, B. Marinelli, R. Weissleder, “Reactive Polymer Enables Efficient In Vivo Chemistry,” Proc. Natl. Acad. Sci. USA, 2012, 109 (13), 4762-4767.

 

16. N. K. Devaraj, R. Weissleder “Biomedical Applications of Tetrazine Cycloadditions,” Acc. Chem. Res., 2011, 44(9), 816-827.

 

15. J. B. Haun, N. K. Devaraj, B. S. Marinelli, H. Lee, R. Weissleder “Probing Intracellular Biomarkers and Mediators of Cell Activation Using Nanosensors and Bioorthogonal Chemistry” ACS Nano, 2011, 5 (4), 3204-3213.

 

14. J. B. Haun, N. K. Devaraj, S. A. Hilderbrand, H. Lee, R. Weissleder “Bioorthogonal Chemistry Amplifies Nanoparticle Binding and Enhances Signal Detection” Nat. Nanotechnol., 2010, 5(9), 660-5.

 

13. H. S. Han, N. K. Devaraj, J. Lee, S. A. Hilderbrand, R. Weissleder, M. G. Bawendi “Development of a Bioorthogonal and Highly Efficient Conjugation Method for Quantum Dots Using Tetrazine Norbornene Cycloaddition” J. Am. Chem. Soc., 2010, 132(23), 7838-9.

 

12. N. K. Devaraj, S. A. Hilderbrand, R.Upadhyay, R. Mazitschek, R. Weissleder “Bioorthogonal Turn-On Probes for Imaging Small Molecules Inside Living Cells” Angew. Chem. Int. Ed., 2010, 49(16), 2869-2872.

 

11. N. K. Devaraj, R. Upadhyay, J. B. Haun, S. A. Hilderbrand, R. Weissleder “Fast and Sensitive Pretargeted Labeling of Cancer Cells via Tetrazine/Trans-Cyclooctene Cycloaddition” Angew. Chem. Int. Ed., 2009, 48(38), 7013-7016.

 

10. N. K. Devaraj, E. J. Keliher, G. M. Thurber, M. Nahrendorf, R. Weissleder “18F Labeled Nanoparticles for in-vivo PET-CT Imaging” Bioconjugate Chem., 2009, 20(2) 397-401.

 

9. N. K. Devaraj, R. Weissleder, S. A. Hildebrand “Tetrazine-Based Cycloadditions: Application to Pretargeted Live Cell Labeling” Bioconjugate Chem., 2008, 19(12), 2297-2299.

 

8. N. K. Devaraj, J. P. Collman, “Copper Catalyzed Azide-Alkyne Cycloadditions on Solid Surfaces: Applications and Future Directions” QSAR and Comb. Sci., 2007, 26(11), 1253-1260.

 

7. J. P. Collman; R. A. Decreau; Y. Yan; Y. Yang; N. K. Devaraj, “Synthesis of Cytochrome c Oxidase Models that can be Covalently Attached onto Electrode Surfaces” J. Org. Chem., 2007, 72(8), 2794-2802.

 

6. J. P. Collman, N. K. Devaraj, R. A. Decreau, Y. Yang, Y. Yan, W. Ebina, T. A. Eberspacher, C. E. D. Chidsey, “A Cytochrome c Oxidase Model Catalyzes the Four-Electron Reduction of Oxygen under Rate-Limiting Electron Flux” Science, 2007, 315, 5818, 1565-1568.

 

5. N. K. Devaraj, R. A. Decreau, J. P. Collman, C. E. D. Chidsey, “Rate of Interfacial Electron Transfer Through the 1,2,3-Triazole ‘Click’ Linkage,” J. Phys. Chem. B., 2006, 110(32), 15955-15962.

 

4. J. P. Collman, N.K. Devaraj, T. A. Eberspacher, C. E. D. Chidsey, “Mixed Azide-terminated Monolayers; A Platform for Modifying Electrode Surfaces,” Langmuir, 2006, 22(6), 2457-2464.

 

3. N. K. Devaraj, P. H. Dinolfo, C. E. D. Chidsey, J. P. Collman, “Selective Functionalization of Independently Addressable Microelectrodes by Electrochemical Activation and Deactivation of a Coupling Catalyst,” J. Am. Chem. Soc., 2006, 128 (6), 1794 -1795.

 

2. N. K. Devaraj, G. P. Miller, W. Ebina, B. Kakaradov, J. P. Collman, E. T. Kool, C. E. D. Chidsey, “Chemoselective Coupling of Oligonucleotides to Self Assembled Monolayers,” J. Am. Chem. Soc., 2005, 127(24), 8600-8601.

 

1. J. P. Collman, N. K. Devaraj, C. E. D. Chidsey, “Clicking Functionality onto Electrode Surfaces,” Langmuir, 2004, (20), 1051-1053.